Research Scientist - Dr. Amantha Thathiah's LaboratoryUniversity of Pittsburgh

We are seeking a Research Scientist to join Amantha Thathiah's lab in the Department of Neurobiology. The focus of the research in the Thathiah lab is to study the cellular and molecular mechanisms involved in the pathogenesis of Alzheimers disease (AD). Neuropathologically, the brains of AD patients are characterized by the accumulation of aggregates of the amyloid- (A) peptide and neurofibrillary tangles, which are composed of the hyperphosphorylated microtubule-associated protein tau. The Thathiah lab investigates the involvement of G protein-coupled receptors (GPCRs) in modulation A and tau pathology and the cross-talk between A and tau in disease progression. We combine cellular and biochemical techniques with mouse models of neurodegeneration and behavioral studies to address our research questions.

Conducts independent scientific research projects from inception to presentation. Prepares and crafts various documentations of research results into manuscripts, proposals, grant applications, and presentations. Trains undergraduates and research technicians. Manages laboratory policies and coordinates project development in collaboration with other specialists.

The Thathiah Laboratory at the University of Pittsburgh School of Medicine is seeking a highly motivated and skilled scientist to lead a newly established NIH-funded Cellular Modeling Core (CMC). The CMC Lead will oversee the generation, maintenance, and characterization of cellular models, derived from both human and non-human primate fibroblasts, to support Alzheimer’s Disease research. This position involves working with marmoset-derived cell lines, optimizing reprogramming techniques, and developing in vitro models to study disease mechanisms. The ideal candidate will have expertise in cell culture, cellular reprogramming techniques (i.e., iPSC and direct conversion), molecular biology and biochemical techniques, and will play a key role in advancing translational research within a collaborative, cutting-edge scientific environment.

Wet lab bench work, which involves sitting/standing/moving around.