Group Leader, Metabolism
- Military veterans preferred
2024-05-15 AppCast (https://www.appcast.io)
Other
/yr
full-time
employee
South San Francisco California 94083 United States
Company info
NewLimit is a biotechnology company working to radically extend human healthspan. We're developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale. Description
NewLimit is seeking an experienced drug discovery leader to guide our Metabolism team. Our Metabolism team is developing reprogramming medicines to restore youthful function in aged hepatocytes in the context of metabolic disease.
In this role, you will develop and perform assays for hepatocyte function, contribute to team decision making, and serve as a subject matter expert within NewLimit to enable our therapeutic development efforts.
As the leader of the Metabolism team, you will:
Lead a team of Scientists (liver biologists) and Research Associates to develop epigenetic reprogramming therapies while remaining involved in day-to-day execution
Collaborate with our Single Cell Technology, Epigenetic Editing, and Predictive Modeling teams to design, build, and test epigenetic reprogramming interventions for aged and diseased hepatocytes
Contribute to NewLimit's product development decisions, company-wide goals, and technology platform
Serve as a company-wide expert on metabolic diseases and liver biology
Develop assays to measure hepatocyte function both ex vivo and in vivo
Evaluate epigenetic reprogramming payloads using ex vivo and in vivo functional assays to select therapeutic candidates
Requirements
Ph.D. in cell biology, molecular biology, biochemistry or a related field or equivalent industry experience (5+ years)
Experience leading a cross-functional team and managing direct reports
Experience with therapeutic development, as demonstrated through contributions to a pre-clinical or clinical stage program
Experience designing and executing experiments in animal models
Experience with target ID and validation
Nice to have
Experience with in vivo nucleic acid delivery technologies (e.g. viral vectors, endosomes, lipid nanoparticles)
Experience with bulk and single cell functional genomics methods
Experience with iterative product development cycles (e.g. design-build-test-learn)
Knowledge of metabolic disease, liver biology, and relevant therapeutic modalities
Benefits
NewLimit offers generous benefits to ensure our team can focus on our mission:
Health, dental, and vision insurance
401(k) with company match
Paid parental leave
Industry-leading paid time off (PTO) - 20 days/year for all employees + holidays