2024-05-15
AppCast (https://www.appcast.io)
Other
/yr
full-time
employee
San Antonio
Texas
78208
United States
Job Type
Full-time
Description
Contribute to the generation and validation of one GLP-CVV for delivery to CDC. This includes delivery of Batch Production Records, Quality documents and any other relevant information associated with the CVV.
The Role:
•Develop draft SOPs in strict accordance with FDA's 21 CFR 58 GLP regulations, including quality assurance qualification of all laboratory reagents
•Cloning or synthesizing the HA and NA genes into CDC provided/approved reverse genetics vectors compatible for virus rescue and prepare high quality plasmids in compliance with GLP regulations
•Perform laboratory research to determine the optimal HA and NA constructs before rescuing each of the GLP-CVV
•Provide antigenicity testing
•Perform hemagglutination assay (HA) using turkey red blood cells to confirm the GLPCVV stock
•Perform Egg Infectious Dose 50 (EID50) assay to confirm the GLP-CVV stock meets a minimum infectious titer that will be communicated when the information/materials are provided by CDC
•Prepare Batch Production Records (BPR) and other quality document
Our Ideal Candidate:
•BA/BS with 3-10+ years' experience, MS with 0-7+ years' experience or PhD with 0-3+ years' experience.
•Knowledge of propagation and adaptation of influenza virus in embryonated chicken eggs.
•Must pass pre-employment qualifications of Cherokee Federal
Who We Are:
Cherokee Nation Operation Solutions (CNOS) provides support, services, and solutions to federal and commercial customers. The company takes a personalized approach to solving our clients' toughest challenges, helping you make the most of your skills. CNOS is part of Cherokee Federal - a team of tribally owned federal contracting companies. For more information, visit cherokee-federal.com.
Your work location will be at the Texas Biomedical Research Institute in San Antonio, TX. Texas Biomedical Research Institute is the only private, non-profit infectious disease research facility, providing high containment research capabilities (BSL3 & BSL4) alongside a National Primate Research Center. You will work closely with collaborators at Cherokee Nation Operational Solutions and Texas Biomedical.
Texas Biomedical Research Institute provides equal employment opportunities for all qualified employees and applicants without regard to race, color, sex, sexual orientation, gender identity, religion, national origin, disability, veteran status, age, marital status, pregnancy, genetic information, or other legally protected status.
