Kikiktagruk Inupiat Corporation, LLC
Senior Bacterial Core Technician
Closing Date: Until Filled
Department: Midnight Sun Professional Solutions
Location: Frederick, MD, USA
Employment Type: Full Time
Title: Senior Bacterial Core Technician
Location: Frederick, MD
Status: Full Time
Salary Range: $60,000-$90,000
Position Summary:
USAMRIID, located at Fort Detrick, Maryland, works closely with other U.S. Army Medical Research and Development Command (USAMRDC) organizations, Department of Defense (DoD), the Interagency (including Interagency Laboratories), and private companies to accomplish its mission of protecting the Warfighter from biological threats and being prepared to investigate disease outbreaks or threats to public health. This includes conducting Research, Development, Testing, & Evaluation (RDTE) of medical countermeasure against biological threats and the safety, quality assurance, project management, and core support required for these research activities.
The Molecular Biology Division works to combat biological threats and weapons of mass destruction by developing high-throughput sequencing and protein profiling to identify emerging pathogens. It also evaluates and improves medical countermeasures, follows the DoD's roadmap for their development, and ensures their ethical use, including FDA approval. The Division also explores expanding indications and combinations with existing countermeasures.
The Automation And Assay Research Scientist shall provide Robotic Liquid Handling Automation support for research efforts of the TDC. Support will be required mainly in BSL-2 environment with subsequent potential support in BSL-3, and BSL-4 environments. Scientist will conduct basic and applied research on current and emerging threats in support of the BD and infectious disease program. They shall aid in the execution of scientific studies-throughput screening assays, enzymatic assays, collection/data analysis, maintain the laboratory and respective laboratory equipment. This position is contingent upon contract award.
Duties/Responsibilities:
- Be responsible for BSL-3 laboratory operations and training in animal manipulations. Contract technicians shall perform approximately 5 animal studies in both the DTRA funded projects as well as contracted work.
- Perform in vitro Minimum Inhibition Concentration (MIC) testing of potential therapeutic compounds against Tier 1 bacteria. We currently utilize 30-strain diversity sets of Bacillus anthracis (anthrax), Yersinia pestis (plague), Francisella tularensis (tularemia), Burkholderia mallei (glanders), and Burkholderia pseudomallei (meliodosis), testing over 72 compounds per year against all 30 strains, in vitro.
- Participate in mouse, rat, rabbit, or other small animal studies, which include preparation of antibiotics for administration, administering drugs and vaccines, orally and by intraperitoneal, intramuscular, subcutaneous, and intravenous bolus injections. In addition, collect animal body fluids and remove tissues with all small animal studies executed. Upon execution of experiment all Contractors shall perform animal health exams to ensure study remains in compliance with IACUC approved protocols.
- Participate in weekly lab meetings and assist in development and design with current and future in vitro and in vivo work. May be requested to present posters at 1 scientific conference which may require CONUS or OCONUS travel and work to be performed outside normal business hours.
- Participate in mouse, rat, rabbit, or other small animal BSL-2 pharmacokinetics and toxicology studies; to include preparation of antibiotics for administration; administering drugs and vaccines, followed by blood and tissue collection for pharmacokinetic or pharmacodynamic analyses.
- Support the in vivo pharmacology research program and contribute to the multidisciplinary research team to determine pharmacokinetics and pharmacodynamics relationships and efficacy of optimized leads.
- Assist with data analyses and drafting of reports for internal or external customers.
- Work with mass spectrometry, chromatography, HPLC MS/MS, specifically Sciex platforms coupled with Shimadzu HPLCs other and biophysical techniques to support in-process testing and characterization of biopharmaceutical products and impurities.
- Perform bioanalytical data acquisition, data analysis, and reporting of results using Applied Biosystems Analyst, Excel, and the Mass Spec Quantitation Software MultiQuant.
- Complete approximately 25 media/reagent preparations per year.
- Assist with approximately 5 animal challenges per year and 10 bacterial challenge preparations.
- Perform approximately 400 animal injections per year; 400 animal observations per year.
- Support divisional in vivo projects by completing approximately 500 bacterial burdens in animal tissue per year.
- Perform approximately 500 small animal necropsies per year.
- Process approximately 300 animal gavage and approximately 125 animal blood collections per year.
- Place approximately 50 GFEBs orders per year for supplies and equipment.
- Maintain laboratories in BSL-2 and BSL-3.
- Perform or assist with BSAT Inventory Management weekly (to include applicable BSAT working stock material).
- Conduct or assist with Equipment Inventory Management twice a year in BSL-2 and BSL-3.
- Perform or assist with monthly Laboratory Management to include safety functions and chemical inventory.
- Review relevant literature monthly. May assist in the preparation standard operating procedures and manuscripts relating to their research efforts. The Contractor may be expected to present research findings at one scientific conference per year, which may require CONUS or OCONUS travel. Contractor shall present results in written and oral format publicly and internally as requested.
- Maintain a GLP training folder and be compliant with all GLP regulations when applicable.
- Directly contribute to the design, rationale, and be point-of-contact for 10 small animal studies to include drafting of a study plan and oversight of personnel scheduling.
- Contribute to study progress reports and scientific manuscripts to include statistical analysis, data compilation, figure preparation, and methods summary.
- Assist in establishing up to 28 new active material transfer agreements and cooperative research and development agreements with up to 8 pharmaceutical companies and/or universities. Contractor shall maintain records of active agreements and collaborations.
- CS-PRP enrollment is required and shall be held and maintained IAW the provisions in this contract and all applicable regulations.
- BPRP enrollment is required and shall be held and maintained IAW the provisions in this contract and all applicable regulations.
Minimum Requirements:
- PhD or D.V.M with research experience in the fields of bacteriology, animal physiology, or similar field of research.
- Experience working under high containment (BSL-3 and ABSL-3) are preferred.
- 3+ years of research experience in the fields of bacteriology, animal physiology, or similar field.
- Prior experience designing, executing and analyzing all stages of complex studies including regulatory requirements associated with the FDA-animal rule.
- Must be able to obtain/maintain a Secret Clearance.
- Active Secret Clearance preferred.
- Must be eligible to enroll in the BPRP and CS-PRP programs.
- Active BPRP and/or CS-PRP status preferred.
Work Environment:
Physical Demands:
Benefits:
KIC offers a comprehensive benefits package to eligible full-time employees including: Medical, Dental, and Vision Insurance, 401k with Match, Life and ADD Coverage, Short and Long Term Disability, Paid Time Off and Holidays, Education Assistance/Tuition Reimbursement, Employee Assistance Program, Employee Discount Program, and more!
Apply online at our website: https://kikiktagruk.applicantpool.com/
Disclaimer:
This is not to be an exclusive list of all responsibilities, duties, and skills required of the person in this job. KIC is an Equal Opportunity Employer. KIC considers all applicants for employment without regard to race, color, sex, national origin, religion, age, physical or mental disability, veteran's status or any other legal protected status.
Pursuant to The Alaska Native Claims Settlement Act 43 U.S.C. Sec. 1601 et seq., and federal contractual requirements, Kikiktagruk Inupiat Corporation, may legally grant certain preference in employment opportunities to KIC Shareholders, and their Descendants.
Successful candidates must adhere to KIC's Drug and Alcohol policy/testing requirements and may be required to pass a background and/or Motor Vehicle Records check.
The salary range for this position is based on several factors, including relevant experience, education, skills, and current market conditions.
Equal employment opportunity, including veterans and individuals with disabilities.
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