Principal Scientist / Principal Engineer - Peptide Manufacturing - Military veterans preferred

Cambrex


Principal Scientist / Principal Engineer - Peptide Manufacturing

US-MA-Waltham

Job ID: 2025-4423
Type: Regular Full-Time
# of Openings: 1
Category: Engineering
Cambrex - Waltham

Overview

About the Company

Snapdragon Chemistry, Inc. is a leader in chemical process development with expertise in continuous flow and process intensification technologies. Our company is catalyzing the transformation of research, development, and manufacturing across the pharmaceutical and fine chemical industries where organic chemistry underpins product development.

We rely on our most valuable resource – our people – to maintain a leadership position in this market. As part of our dynamic team, you will have the opportunity to collaborate with world-class leaders in flow chemistry and product development while also cultivating and furthering your career.  At Snapdragon Chemistry, we strive to create an environment of innovation and excellence where mutual respect and teamwork underpin our culture.

Position Summary

Cambrex Snapdragon Boston is currently seeking exceptional candidates for its Principal Scientist / Principal Engineer – Peptide Manufacturing position at its Waltham, MA R&D center. A successful candidate will be joining a group of innovative and entrepreneurial engineers and scientists to enable the delivery of high quality, complex chemical matter to our clients.

We are seeking a highly experienced and innovative Principal Scientist or Principal Engineer with deep expertise in peptide synthesis and manufacturing to lead the development, scale-up, and commercialization of peptide-based drug substances. This role will be pivotal in bridging R&D and GMP manufacturing, optimizing synthetic strategies, and ensuring robust, compliant, and efficient peptide production processes.

Responsibilities

• Lead process development and scale-up of peptide synthesis, including solid-phase peptide synthesis (SPPS), solution-phase synthesis, cleavage, purification, and lyophilization.
• Design and execute DOE studies to optimize reaction conditions, resin loading, coupling strategies, and purification and isolation methods (e.g., RP-HPLC, IEC, TFF, lyophilization).
• Evaluate and select appropriate resins, reagents, and solvents for phase-appropriate manufacturing.
• Partner with analytical development to define and control critical quality attributes (CQAs) and critical process parameters (CPPs).
• Lead tech transfer of peptide processes to internal or external GMP manufacturing sites; serve as technical SME during manufacturing campaigns.
• Author and review process development reports, batch records, validation protocols, CMC documentation (e.g., Module 3), and regulatory filings (IND, NDA).
• Collaborate cross-functionally with QA, QC, regulatory, and supply chain to ensure technical alignment and compliance.
• Troubleshoot scale-up issues, support deviation investigations, and lead process improvements based on data-driven risk assessments.
• Mentor junior scientists and engineers; contribute to building peptide capabilities and infrastructure.

Education:

• PhD. in Organic Chemistry, Chemical Engineering, Pharmaceutical Sciences, or related field, with 5–8+ years of peptide manufacturing experience; or M.S./B.S. with 10+ years in peptide process development or GMP manufacturing.

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