Medicinal Chemistry Consultant - Military veterans preferred

Kikiktagruk Inupiat Corporation, LLC

Medicinal Chemistry Consultant
Closing Date: Until Filled
Department: Midnight Sun Professional Solutions
Location: USA
Employment Type: Part Time

Title: Medicinal Chemistry Consultant

Location: Remote

Status: Part-Time

Travel: Limited Travel (anticipated 8 hours annually)

Salary Range: $100 - $150 per hour

Position Summary:

The NIH Blueprint for Neuroscience Research, a consortium of 8 NIH Institutes and Centers that support neuroscience research, established the Blueprint Neurotherapeutics Network (BPN) as a pipeline between the typical endpoint of NIH-funded research and the beginning of industry drug development. The BPN provides neuroscience researchers with funding and access to a full range of industry-style drug development services and expertise. The program is intended for projects requiring medicinal chemistry optimization and contract research organization (CRO) support through Phase I clinical testing. Each project is directed by a Lead Development Team (LDT) composed of the principal investigator (PI), industry consultants hired by NIH, and NIH staff. This team maps out a research strategy, including milestones, and oversees implementation by CROs.

The Medicinal Chemistry Consultant shall provide this support while serving on NIH BPN Lead Development Teams. Lead Development Teams (LDT) meet for approximately two hours every one to two weeks via teleconference and each LDT project may require between three and ten hours weekly, inclusive of meeting and preparation time. The Medicinal Chemistry Consultant is expected to provide support services in a collaborative way. Lead Development Teams the Medicinal Chemistry Consultant is assigned to may work on a number of projects in the exploratory through preclinical safety stages. Some projects may proceed to investigational new drug (IND) and clinical trial stages.

Duties/Responsibilities:

• Offer input on project milestones, target product profiles, and testing funnels.
• Provide feedback on chemical structures and processes proposed by a chemistry service contractor for each round of SAR.
• Evaluate SAR data on a weekly or biweekly basis.
• Evaluate the potential tractability (including surrounding IP space) of a chemical structure for medicinal chemistry. Specific consulting responsibilities will depend on the expertise of the individual consultant and the needs of individual projects.
• Advise strategically plan, and manage medicinal chemistry programs to facilitate exploratory chemistry, hit-to-lead, lead optimization, IND enabling, and clinical studies.
• Serve as the medicinal chemistry expert in order to identify potential drug discovery and developmental challenges and suggest strategies to address challenges.
• Collaborate on design of investigative studies in support of NOH drug discovery and developmental projects.
• Review Medicinal Chemistry sections of regulatory filings provided by the CRO's or PI's.
• Accompany NIH Staff or visit, at NIH Program Staff requests, Contract Research Organizations (CROs) under contract to the NIH (e.g. NIH Blueprint Neurotherapeutics Network (BPN) or the NIH Helping to End Addiction Long Term (HEAL). Assist the NIH staff in inspecting facilities and discuss appropriateness of CRO proposed methodology.
• Facilitate Lead Development Team discussions via telephone and email regarding assigned medicinal chemistry efforts.
• Work in a cross-functional team environment and manage competing priorities.
• Educate and build trust with LDT members of many disciplines to build consensus and maintaining focus of team on milestone achievement.
• Participate actively in LDT discussions.
• Other duties as assigned.

Minimum Requirements:

• A PhD degree in chemistry or medicinal chemistry is required.
• 15+ years of medicinal chemistry experience - required.
• Experience in managing drug discovery and early development (e.g., Phase 1 clinical) medicinal chemistry efforts as evidenced by employment as an executive (senior scientific)-leader in the biopharmaceutical industry or as an experienced consultant providing the same services. Experience with drug discovery for nervous system conditions is preferred.
• Experience with antibody conjugates chemistry, peptides, siRNA synthesis is a plus.
• Experience in executing and managing drug development tasks, preferably with experience in developing drugs for nervous system conditions preferred but not required.
• A track record of advancing projects into drug development. Measures of success include patents , Investigational New Drug (IND) applications, publications, and drugs brought to market.
• Experience in identifying and anticipating problems early in a project, overcoming technical difficulties, and making strategic decisions that make wise use of limited resources (including terminating projects that appear unlikely to succeed) will be considered as signs of a strong track record in drug development.
• Expertise leading chemistry efforts performed by contract research organizations and managing drug project portfolios.
• Experience in therapeutics for CNS and pain relief will be considered a plus.
• Experience working with multi-disciplinary teams at a senior level in the biopharmaceutical industry, especially teams with members from outside organizations and members at various management levels.
• Strong interpersonal skills, an attention to detail, excellent organizational, writing, communication, presentation, and documentation skills as well as computer and software literacy.

Apply online at our website: https://kikiktagruk.applicantpool.com/

Disclaimer:

This is not to be an exclusive list of all responsibilities, duties, and skills required of the person in this job. ?KIC is an Equal Opportunity Employer as to all protected groups, including protected veterans and individuals with disabilities.

Pursuant to The Alaska Native Claims Settlement Act 43 U.S.C. Sec. 1601 et seq., and federal contractual requirements, Kikiktagruk Inupiat Corporation, may legally grant certain preference in employment opportunities to KIC Shareholders, and their Descendants.

Successful candidates must adhere to KIC's Drug and Alcohol policy/testing requirements and may be required to pass a background and/or Motor Vehicle Records check.

The salary range for this position is based on several factors, including relevant experience, education, skills, and current market conditions.??

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